基本信息INFORMATION
闫俊艳
联系方式 CONTACT
地址:6号综合楼B409
邮箱:yanjunyan224422@163.com
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个人简介PERSONAL PROFILE
理学博士,硕士生导师
教育经历:
2014.9-2017.7,中国科学院苏州纳米技术与纳米仿生研究所,细胞生物学,博士
2010.9-2013.7,中国农业科学院研究生院,生物化学与分子生物学,硕士
2006.9-2010.7,武汉轻工大学,动物科学,本科
工作经历:
2023.1至今,绍兴文理学院,副教授
2019.1-2022.12,绍兴文理学院,讲师
2017.9-2018.4,江苏省血吸虫病防治研究所,科研人员
2013.7-2014.3,中国科学院微生物研究所,科研助理
教学工作 EXPERIENCE
主讲的课程:《动物生理学》、《生物医用材料》、《微生物技术与应用》、《药膳与养生》
研究方向RESEARCH DIRECTION
(1)纳米材料及环境污染物的生物毒理
目前纳米科技运用十分多元,人们可以通过注入纳米药物或长期暴露于纳米材料生产车间等途径,引发纳米安全性的困扰。因此,纳米安全性的研究将成为纳米科学领域所必须迫切关注的议题。另外,PM2.5环境问题日益凸显,PM2.5引发的肺部及心血管毒性机制尚不明确,亟待深入研究。
(2)干细胞示踪剂的研发及利用
针对目前干细胞移植在中枢神经损伤、肝衰竭、尘肺等重大疾病修复治疗中亟需的体内示踪要求,我们拟构建安全、高效的纳米示踪剂,实现对移植干细胞实时、高灵敏、高特异性的体外或体内示踪。
科研项目RESEARCH FIELD
1. 基于细胞免疫荧光法神经系统自身免疫性疾病抗体检测试剂盒的开发及应用,计划外、技术研发项目,100万,2022.05-2024.04,在研,主持。
2.骨髓间充质干细胞和ROCK抑制剂联合治疗PM2.5诱发肺损伤的研究,浙江省自然科学基金,2020.1-2022.12,在研,主持。
3. 基于智能化细胞膜密度传感系统提升微载体规模化细胞制药的综合技术研发,计划外、技术研发项目,100万,2019.11-2021.10,第二参与人。
4. 不同粒径细颗粒物对人脐带间充质干细胞毒性及分化潜能的研究,绍兴文理学院科研启动基金,2018.07- 2020.07,主持,已结题。
研究成果RESEARCH FINDINGS
主要发表论文:
1. Junyan Yan, Baowei Hu, Wenjie Shi, Xiaoyi Wang, Jiayuan Shen, Yaping Chen, Huarong Huang, Lifang Jin*. Gli2-regulated activation of hepatic stellate cells and liver fibrosis by TGF-β signaling. American Journal of Physiology-Gastrointestinal and Liver Physiology,2021,320,G720–G728
2. Junyan Yan, Yaxin Tang, Xin Zhong, Huarong Huang, Haonan Wei, Yulei Jin, Yanjiang He, Jinqiao Cao, Lifang Jin* and Baowei Hu*. ROCK inhibitor attenuates carbon blacks-induced pulmonary fibrosis in mice via Rho/ROCK/NF-kappa B pathway. Environmental toxicology,2021,36 (7),1476-1484
3. Junyan Yan, Huarong Huang, Zuping Liu, Jiayuan Shen, Jian Ni, Jiwei Han, Renjun Wang, Deron Lin, Baowei Hu*, Lifang Jin*. Hedgehog signaling pathway regulates hexavalent chromium induced liver fibrosis by activation of hepatic stellate cells. Toxicology Letter,2020,320,1-8
4. Junyan Yan, Lifang Jin, Derong Lin, Chia-Hsiang Lai, Zhongjuan Xu, Renjun wang, Yi-Chun Chen, Baowei Hu* and Chia-Hua Lin*. PM2.5 collecting in a tire manufacturing plant affects epithelial differentiation of human umbilical cord derived mesenchymal stem cells by Wnt/β-catenin pathway. Chemosphere,2019,244,125441
5. Lifang Jin, Jian Ni, Yuan Tao, Xinyi Weng, Yuling Zhu, Junyan Yan* and Baowei Hu*. N-acetylcysteine attenuates PM2.5-induced apoptosis by ROS-mediated Nrf2 pathway in human embryonic stem cells.Science of the Total Environment,2019,666,713-720
6. Junyan Yan#, Shulan Hou#, Yanzhen Yu, Yong Qiao, Tongqian Xiao, Yan Mei, Zhijun Zhang, Bin Wang, Chih-Ching Huang, Chia-Hua Lin* and Guangli Suo*. The effect of surface charge on the cytotoxicity and uptake of carbon quantum dots in human umbilical cord derived mesenchymal stem cells. Colloids and Surfaces B Biointerfaces, 2018,171,241-249
7. Junyan Yan, Chih-Ching Huang, Shih-Chun Candice Lung, Wen-Cheng Wang, Guangli.Suo, Yu-Jing Lin, Chia-Hsiang Lai* and Chia-Hua Lin*. ROCK inhibitor attenuated early atherosclerosis caused by occupational environmental concentrations of carbon black nanoparticles. Environmental Science: Nano, 2017, 4(7),1525-1533
8. Junyan Yan#, Chia-Hsiang Lai#, Shih-Chun Candice Lung, Wen-Cheng Wang, Pin-I Huang, Chia-Hua Lin*. Daily alveolar deposition dose of PM2.5 extracts cause pulmonary adverse effect through RhoA/ROCK pathway. Science of the Total Environment, 2017,599–600:1658–1666.
9. Junyan Yan#, Chia-Hsiang Lai#, Shih-Chun Candice Lung, Wen-Cheng Wang, Chih-Ching Huang, Guan-Wen Chen, Guangli Suo, Cheng-Tai Choug, Chia-Hua Lin*. Carbon black aggregates cause endothelial dysfunction by activating ROCK. Journal of Hazardous Materials, 2017,338,66-75
10. Junyan Yan, Liliang Chen, Chih-Ching Huang, Lingyan Yang, Wen-Cheng Wang, Po-Hsiung Lin, Guangli Suo* and Chia-Hua Lin*. Consecutive evaluation of graphene oxide and reduced graphene oxide nanoplatelets immunotoxicity on monocytes. Colloids and Surfaces B Biointerfaces, 2017,153,300-309
11. Junyan Yan, Qiao Y, Hu J, Ding HB*. Cloning, expression and characterization of a trehalose synthase gene from Rhodococcus opacus. Protein J,2013,32,223-229


荣誉奖励 HONOR AWARD
2022年度院级优秀教师、校级优秀班主任
2021年度校级优秀教师

指导学生竞赛:
1.2022年浙江省第十四届大学生生命科学竞赛,省三等奖,1/2
2.2021年浙江省第十三届大学生生命科学竞赛,省二等奖,1/2
3.2019年浙江省第十一届大学生生命科学竞赛,省三等奖,2/1
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