基本信息INFORMATION
谢昕
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xiexin0922@126.com
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2006年获得全额奖学金于香港中文大学攻读生物学学士学位，2010年获甲等荣誉毕业并保送至香港中文大学生命科学学院攻读分子生物学硕士学位。2012年获得剑桥大学全额资助于世界著名生命科学研究中心：剑桥大学-分子生物学实验室攻读分子免疫学博士学位。2016年顺利完成博士学位并就职于纽约大学阿布扎比分校。2022年获得浙江省海外高层次人次引进计划青年项目，受聘于浙江省绍兴文理学院
化合物生物功能筛选，氧化应激和铁死亡，分子免疫学
2010-2012: 筛选大豆分离化合物对癌细胞凋亡恢复的抑制作用：主要完成人。
2012-2015: Foxp3 蛋白结构域在控制调节性 T 细胞转录组中的功能剖析：主要完成
人。
2016-2019: 研究核肌动蛋白在基因组组织调控和细胞命运控制中的新功能：主
持和主要完成人。
2018-2020：研究脂质代谢在肿瘤微环境中 Treg 功能中的作用，合作项目：瑞士洛桑大学PC Ho 教授
2019-2021: 从海湾地区分离的海洋细菌中筛选生物活性化合物：项目管理。
2020-2021: 为纽约大学社区建立 Covid-19 微流控体纳米 qPCR 检测平台：项目经理：
Covid-19 实验室经理和协调员，协调包括平台建立、方法验证、SOP 准备、数据库设计等。
2020-至今：研究肿瘤相关巨噬细胞 (TAM) 的线粒体和代谢变化，合作者：台湾国立卫生研究院细胞
与系统医学研究所刘仆慈研究员
2020-至今：高内涵成像分析的化合物筛选，合作者Kristin Gunsalus 教授纽约大学阿布扎比分校基因组学系统生物学中心
2012-2015: Foxp3 蛋白结构域在控制调节性 T 细胞转录组中的功能剖析：主要完成
人。
2016-2019: 研究核肌动蛋白在基因组组织调控和细胞命运控制中的新功能：主
持和主要完成人。
2018-2020：研究脂质代谢在肿瘤微环境中 Treg 功能中的作用，合作项目：瑞士洛桑大学PC Ho 教授
2019-2021: 从海湾地区分离的海洋细菌中筛选生物活性化合物：项目管理。
2020-2021: 为纽约大学社区建立 Covid-19 微流控体纳米 qPCR 检测平台：项目经理：
Covid-19 实验室经理和协调员，协调包括平台建立、方法验证、SOP 准备、数据库设计等。
2020-至今：研究肿瘤相关巨噬细胞 (TAM) 的线粒体和代谢变化，合作者：台湾国立卫生研究院细胞
与系统医学研究所刘仆慈研究员
2020-至今：高内涵成像分析的化合物筛选，合作者Kristin Gunsalus 教授纽约大学阿布扎比分校基因组学系统生物学中心
1. Xin Xie, et al. 2020. Microfluidic Nano-Scale qPCR Enables Ultra-Sensitive and Quantitative Detection of SARS-CoV-2. Processes. 8(11), 1425.
2. Giusy Di Conza, Chin-Hsien Tsai, Hector Gallart Ayala, Yi-Ru Yu, Fabien Franco, Lea Zaffalon, Xin Xie, …, Ping-Chih Ho. 2021. Tumor-induced reshuffling of lipid composition on the ER membrane sustains macrophage survival and pro-tumorigenic activity. Nature Immunology, 22, 1403–1415.
3. Syed Raza Mahmood, Xin Xie, Nadine Hosny El Said, Kristin C. Gunsalus, Piergiorgio Percipalle. 2021. β-actin dependent chromatin remodeling mediates compartment level changes in 3D genome architecture. Nature Communications, 2;12(1):5240.
4. Yugang Guo, Yu-Qing Xie, Min Gao, Yang Zhao, Haiping Wang, Mathias Wenes, Fabien Franco, Hanshuo Yang, Xin Xie, Bing Feng, Yuxi Wang, Weimin Li, Pedro Romero, Ping-Chih Ho, Tang Li. 2021. Metabolic Reprogramming of Terminally Exhausted CD8+ T-cells by Interleukin-10 Enhances Anti-Tumour Immunity. Nature Immunology, 22(6):746-756.
5. Chandrashekhar Murade, Samata Chaudhuri; Ibtissem Nabti; Hala Fahs; Fatima Refai, Xin Xie, Yanthe Pearson, Kristin Gunsalus, George Shubeita. 2021. A FRET‐based probe for high throughput DNA intercalator drug discovery and in vivo imaging. ACS Sensors, 6(6):2233-2240.
6. Tamara Gjorgjieva*, Xin Xie*, et al. 2020. Loss of β-actin leads to accelerated mineralization and dysregulation of osteoblast-differentiation genes during osteogenic reprogramming. Advanced Science, accepted, in press. * Co-first author.
7. Haiping Wang, Fabien Franco, Yao-Chen Tsui, Xin Xie, …, Ping-Chih Ho. 2020. CD36-PPARβ signaling-mediated metabolic adaptation supports intratumoral regulatory T cell survival and function. Nature Immunology, 21(3):298-308.
8. Mohamed Al Sayegh, Raza Mahmood, Miss Salema Abul Khair, Xin Xie, Mei El Gindi, Tina Kim, Alia Almansoori, Piergiorgio Percipalle. 2020. β-actin contributes to an open chromatin for activation of the adipogenic pioneer factor CEBPA during transcriptional reprograming. Molecular Biology of the Cell, 31:2495-2629
9. Xin Xie, SR Mahmood, T Gjorgjieva, P Percipalle. 2020. Emerging roles of cytoskeletal proteins in regulating gene expression and genome organization during differentiation. Nucleus. 11:53-65.
10. Xin Xie, et al. 2019. Mitochondria-localized β-actin is essential for priming antiviral innate immune signaling by regulating IRF3 protein stability. Cellular & Molecular Immunology, 16:837-840
11. Xin Xie, Pu-Ste Liu, Piergiorgio Percipalle. 2019. Analysis of global transcriptome change in mouse embryonic fibroblasts after dsDNA and dsRNA viral mimic stimulation. Frontiers in Immunology 10:836.
12. Xin Xie, Robertas Jankauskas, Aslam M. A. Mazari, Nizar Drou and Piergiorgio Percipalle. 2018. β-actin regulates a heterochromatin landscape essential for optimal induction of neuronal programs during direct reprograming. Plos Genetics. 14(12): e1007846.
13. Xin Xie & Piergiorgio Percipalle. 2018. Elevated transforming growth factor β signaling activation in β‐actin‐knockout mouse embryonic fibroblasts enhances myofibroblast features. J. Cellular Physiology. 233:8884-8895.
14. Xin Xie, Tomas Venit, & Piergiorgio Percipalle. 2018. In Mitochondria β-Actin Regulates mtDNA Transcription and Is Required for Mitochondrial Quality Control. iScience. 3:226-237.
15. Xin Xie, Muhammedin Deliorman, Mohammad A. Qasaimeh & Piergiorgio Percipalle. 2018. The relative composition of actin isoforms regulates membrane biophysical features and cellular behavior. BBA-General Subjects. 1862(5):1079-1090.
16. Xin Xie, et al. 2017. β-actin dependent global chromatin organization and gene expression programs control cellular identity. FASEB Journal. 32(3): 1296-1314.
17. Tomas Venit*, Xin Xie* & Piergiorgio Percipalle. 2018. Actin in the cell nucleus (Book Chapter). Nuclear Architecture and Dynamics. 2: pp345-67. Academic Press (Elsevier). (* equal contribution).
18. Xin Xie & Piergiorgio Percipalle. 2017. An actin-based nucleoskeleton involved in gene regulation and genome organization. Biochemical and Biophysical Research Communication. 506(2):378-386.
19. Xin Xie, et al. 2015. The regulatory T cell lineage factor Foxp3 regulates gene expression through several distinct mechanisms mostly independent of direct DNA binding. Plos Genetics. 11(6): e1005251.
20. Xin Xie, Shan Shan Wang, Timothy Chung Sing Wong and Ming Chiu Fung. 2013. Genistein promotes cell death of ethanol-stressed HeLa cells through the continuation of apoptosis or secondary necrosis. Cancer Cell International 13:1-15.
2. Giusy Di Conza, Chin-Hsien Tsai, Hector Gallart Ayala, Yi-Ru Yu, Fabien Franco, Lea Zaffalon, Xin Xie, …, Ping-Chih Ho. 2021. Tumor-induced reshuffling of lipid composition on the ER membrane sustains macrophage survival and pro-tumorigenic activity. Nature Immunology, 22, 1403–1415.
3. Syed Raza Mahmood, Xin Xie, Nadine Hosny El Said, Kristin C. Gunsalus, Piergiorgio Percipalle. 2021. β-actin dependent chromatin remodeling mediates compartment level changes in 3D genome architecture. Nature Communications, 2;12(1):5240.
4. Yugang Guo, Yu-Qing Xie, Min Gao, Yang Zhao, Haiping Wang, Mathias Wenes, Fabien Franco, Hanshuo Yang, Xin Xie, Bing Feng, Yuxi Wang, Weimin Li, Pedro Romero, Ping-Chih Ho, Tang Li. 2021. Metabolic Reprogramming of Terminally Exhausted CD8+ T-cells by Interleukin-10 Enhances Anti-Tumour Immunity. Nature Immunology, 22(6):746-756.
5. Chandrashekhar Murade, Samata Chaudhuri; Ibtissem Nabti; Hala Fahs; Fatima Refai, Xin Xie, Yanthe Pearson, Kristin Gunsalus, George Shubeita. 2021. A FRET‐based probe for high throughput DNA intercalator drug discovery and in vivo imaging. ACS Sensors, 6(6):2233-2240.
6. Tamara Gjorgjieva*, Xin Xie*, et al. 2020. Loss of β-actin leads to accelerated mineralization and dysregulation of osteoblast-differentiation genes during osteogenic reprogramming. Advanced Science, accepted, in press. * Co-first author.
7. Haiping Wang, Fabien Franco, Yao-Chen Tsui, Xin Xie, …, Ping-Chih Ho. 2020. CD36-PPARβ signaling-mediated metabolic adaptation supports intratumoral regulatory T cell survival and function. Nature Immunology, 21(3):298-308.
8. Mohamed Al Sayegh, Raza Mahmood, Miss Salema Abul Khair, Xin Xie, Mei El Gindi, Tina Kim, Alia Almansoori, Piergiorgio Percipalle. 2020. β-actin contributes to an open chromatin for activation of the adipogenic pioneer factor CEBPA during transcriptional reprograming. Molecular Biology of the Cell, 31:2495-2629
9. Xin Xie, SR Mahmood, T Gjorgjieva, P Percipalle. 2020. Emerging roles of cytoskeletal proteins in regulating gene expression and genome organization during differentiation. Nucleus. 11:53-65.
10. Xin Xie, et al. 2019. Mitochondria-localized β-actin is essential for priming antiviral innate immune signaling by regulating IRF3 protein stability. Cellular & Molecular Immunology, 16:837-840
11. Xin Xie, Pu-Ste Liu, Piergiorgio Percipalle. 2019. Analysis of global transcriptome change in mouse embryonic fibroblasts after dsDNA and dsRNA viral mimic stimulation. Frontiers in Immunology 10:836.
12. Xin Xie, Robertas Jankauskas, Aslam M. A. Mazari, Nizar Drou and Piergiorgio Percipalle. 2018. β-actin regulates a heterochromatin landscape essential for optimal induction of neuronal programs during direct reprograming. Plos Genetics. 14(12): e1007846.
13. Xin Xie & Piergiorgio Percipalle. 2018. Elevated transforming growth factor β signaling activation in β‐actin‐knockout mouse embryonic fibroblasts enhances myofibroblast features. J. Cellular Physiology. 233:8884-8895.
14. Xin Xie, Tomas Venit, & Piergiorgio Percipalle. 2018. In Mitochondria β-Actin Regulates mtDNA Transcription and Is Required for Mitochondrial Quality Control. iScience. 3:226-237.
15. Xin Xie, Muhammedin Deliorman, Mohammad A. Qasaimeh & Piergiorgio Percipalle. 2018. The relative composition of actin isoforms regulates membrane biophysical features and cellular behavior. BBA-General Subjects. 1862(5):1079-1090.
16. Xin Xie, et al. 2017. β-actin dependent global chromatin organization and gene expression programs control cellular identity. FASEB Journal. 32(3): 1296-1314.
17. Tomas Venit*, Xin Xie* & Piergiorgio Percipalle. 2018. Actin in the cell nucleus (Book Chapter). Nuclear Architecture and Dynamics. 2: pp345-67. Academic Press (Elsevier). (* equal contribution).
18. Xin Xie & Piergiorgio Percipalle. 2017. An actin-based nucleoskeleton involved in gene regulation and genome organization. Biochemical and Biophysical Research Communication. 506(2):378-386.
19. Xin Xie, et al. 2015. The regulatory T cell lineage factor Foxp3 regulates gene expression through several distinct mechanisms mostly independent of direct DNA binding. Plos Genetics. 11(6): e1005251.
20. Xin Xie, Shan Shan Wang, Timothy Chung Sing Wong and Ming Chiu Fung. 2013. Genistein promotes cell death of ethanol-stressed HeLa cells through the continuation of apoptosis or secondary necrosis. Cancer Cell International 13:1-15.